NCI-H661 人大細胞肺癌細胞

ATCC® Number:  HTB-183™

Designations:  NCI-H661 [H661]

Depositors:   AF Gazdar, JD Minna

Biosafety Level: 1

Shipped:  frozen

Medium & Serum:  See Propagation

Growth Properties: adherent

Organism: Homo sapiens (human)

Morphology: epithelial

NCI-H661 人大細胞肺癌細胞

Source: Organ: lung

Disease: carcinoma; large cell lung cancer

Derived from metastatic site: lymph node

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Isolation:  Bethesda Maryland,

Isolation date: 1982

DNA Profile (STR): Amelogenin: X,Y

CSF1PO: 10

D13S317: 11

D16S539: 12

D5S818: 11

D7S820: 8,10

THO1: 8

TPOX: 8

vWA: 17

Cytogenetic Analysis: hyperhexaploid; modal number = 142; range = 130 to 153. Each cell had over 70 marker chromosomes. Among the markers were t(1p10q), del(1)(q11/q12), 6q+, 2q+,der(20)t(12;20)(q11;q13). Some of these had 2 to copies per cell. Most cells also had 5 to 10 microchromosomes (metacentric like). Structurally normal N2,N4 and N9 were absent; two copies of the X and multiple copies of the Y were detected.

Isoenzymes:  AK-1, 1

ES-D, 1

G6PD, B

GLO-I, 1-2

Me-2, 0

PGM1, 1

PGM3, 1

Age:  43 years

Gender:  male